1 Identification of a novel Endoplasmic Reticulum Stress Response Element regulated by XBP 1
نویسندگان
چکیده
Background: Endoplasmic reticulum stress (ER stress) maintains protein homeostasis in cells. Results: A novel ER stress-responsive element, ERSE-26, identified in 38 human genes, including PRNP and ERLEC1, is regulated by spliced XBP1 during ER stress. Conclusion: ER stress increases the levels of human prion protein and other proteins not previously known to be involved in the ER stress response. Significance: ERSE-26 implicates novel genes and cellular functions regulated by the ER stress response.
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